Detect & Identify Microbes Within Minutes
GramRay MK3 — Microbiology at the Speed of Light
Microbial control needs repeatability & flexibility — and GramRay MK3 was built for it.
From bioburden and sterility testing to in-process control and R&D, the same instrument adapts to various workflows, providing you with the flexibility to select the most suitable method for each application.
- Bioburden & Environmental Monitoring | Detect & ID contamination sources within 90 min and link findings to root causes.
- Sterility & Release Testing | Achieve same-day release decisions instead of 2–7 day incubation waits.
- In-Process Control (IPC) | Monitor media and equipment hygiene in real time.
- R&D & Database Building | Expand RAMANMETRIX™ libraries for strain-specific identification.
Clean lines, solid feel, compact footprint.
Laser class 1 safety doors, joystick control, intuitive layout – we’ve put a lot of thought into the details you can touch, and even more into the ones you don’t notice right away.
Versatile sample holder, and linear motor precision.
The doors open wide to give you full access – for changing sample formats, fine-tuning positions, or cleaning. The platform is designed for stability, minimal vibration, and effortless handling.
Close the doors. Press start. Done.
Once the samples are in, the GramRay MK3 takes over.
Laser-safe. Fully automated. No further user interaction needed. The system does the work – measuring, detecting, identifying.
Robust enough for routine. Smart enough for precision.
Technology Indistinguishable from Magic
When single-cell Raman analysis, AI-driven targeting, and multimodal imaging merge into one workflow — the result feels like magic.
GramRay MK3 transforms light into knowledge, delivering microbial insight in minutes.
DeepMorph AI – Smarter Detection
DeepMorph identifies potential viable cells before Raman acquisition.
Its model, trained on mibiC’s proprietary illumination and filter data, directs the Raman probe precisely to relevant targets.
RAMANMETRIX™ – Learn Your Own Microbes
Create your own microbial fingerprint library.
Record one species for your RAMANMETRIX™ model in about one hour, then distinguish lab isolates from biofilm-derived strains in just 10 seconds per microbe.
Connect to the Biophotonics Diagnostics curated Raman Microbes Database for confirmation and updates.
Flexible Sample Preparation
No two samples are alike. GramRay accommodates both clear and complex matrices for reproducible results.
Choose the most efficient preparation path for your sample type:
- Filtration mode – for liquids and high-volume samples; cells are concentrated and measured directly on a metal-coated filter.
- Suspension mode – for colonies or unfilterable matrices; apply a 10 µL drop that dries in 5 min for immediate isolate ID or RamanMetrix™ training.
Each mode is optimized for throughput, recovery, and spectral clarity.
Tailored Analytical Modes
Different applications demand different detection strategies.
GramRay MK3 combines imaging, AI, and Raman spectroscopy in a single automated workflow:
- Autofluorescence Detection – differentiates biological from inert particles.
- DeepMorph AI Guidance – trained on hundreds of thousands of images, boosting viable-cell detection ×10.
- Multimodal Raman Analysis – merges dark-field, fluorescence, and Raman for maximum selectivity.
Effortless Mounting & Automation
Mount your sample with a snap. The GramRay MK3 automatically recognizes sample position and starts measurement at the push of a button.
Run a single membrane or up to eight samples in parallel with Auto Focus & Auto Scan routines that image the entire filter in minutes.
Pre-stored methods adjust parameters for bioburden, sterility, or IPC tasks, ensuring push-button reproducibility and full cGMP compliance.
Calibration & Self-Tests
- Autocalibration before every run
- Automatic self-tests for optical / analytical stability
- Includes positive & negative controls for verification
- Ensures traceable, validated performance
Illumination & Multimodality
Dark-Field Illumination — Enhances contrast by capturing only scattered light, allowing for the detection of faint or low-density microbes independent of the surrounding background.
Epi-Fluorescence | precise fluorescent imaging, enabling clear visualization of stained cells even in complex matrices.
Autofluorescence Detection | Identifies naturally fluorescent microbes without staining, allowing fast recognition of biological material amid non-biological particles.
Multimodal Integration | Combines dark-field, fluorescence, and Raman in one automated run, ensuring robust classification of target organisms while filtering out noise and debris.
Illumination+ Module | Offers six selectable light sources from UV to near-IR, providing optimal excitation for diverse fluorophores and supporting reliable detection across varied sample types.
From Sample to Certainty
Filter your liquid sample and detect microbial presence down to a single viable cell per mL.
Optimized filtration and high-sensitivity Raman analysis capture, count, and classify every organism within minutes.
From Colony to Clarity
Take a colony, resuspend, and spot.
Analyze up to 400 microbes per hour for instant identification and effortless database growth.
Regulatory readiness is built in.
- 21 CFR Part 11-compliant user management
- Audit trail & data integrity controls
- cGMP-compliant result generation (pass/fail output, taxonomy, viability)
- ISO 9001-certified manufacturing and full IQ/OQ/PQ documentation